Regulation of Signaling by Non-degradative Ubiquitination
نویسندگان
چکیده
منابع مشابه
Regulation of signaling by non-degradative ubiquitination.
Acentral unifying principle in the field of signal transduction has been the covalent modification of proteins by phosphorylation. A wide range of protein kinases are known, and the process is regulated by a more limited although important number of protein phosphatases. Recently, there has been a remarkable increase in the numbers of examples of another reversible covalent modification in prot...
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Growing evidence supports other regulatory roles for protein ubiquitination in addition to serving as a tag for proteasomal degradation. In contrast to other common post-translational modifications, such as phosphorylation, little is known about how non-degradative ubiquitination modulates protein structure, dynamics, and function. Due to the wealth of knowledge concerning protein kinase struct...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2009
ISSN: 0021-9258
DOI: 10.1074/jbc.r800070200